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Effects of hyaluronic acid injected using the mesogun injector with stamp‐type microneedle on skin hydration
Author(s) -
Choi Sun Young,
Ko Eun Jung,
Yoo Kwang Ho,
Han Hye Sung,
Kim Beom Joon
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13963
Subject(s) - medicine , dermis , hyaluronic acid , placebo , wrinkle , adverse effect , randomized controlled trial , intradermal injection , surgery , dermatology , skin aging , pathology , anatomy , gerontology , alternative medicine , immunology
The elasticity of the skin and its capacity to hold water decrease with aging because of the loss of hyaluronic acid (HA) in the skin. Therefore, there is an increasing interest in the use of HA fillers in skin rejuvenation beyond its conventional use which is supplementing decreased dermis volume and filling deep wrinkles. We investigated the efficacy and safety of a novel device (Dermashine balance) that injects HA into the dermis using a stamp‐type microneedle for maintenance of hydration and elasticity of the skin. A single‐center randomized double‐blinded parallel‐group clinical study was conducted, and 60 participants enrolled in this study. The subjects were randomized to receive HA injections or a placebo three times across the face using an automatic intradermal injector. At 4, 8, and 12 weeks after the treatment, skin hydration was measured using a corneometer. The patients who received HA showed significantly greater skin hydration than those who received the placebo. However, a significant difference was not noted in skin elasticity between the groups. No severe adverse event was reported. Intradermal supplementation of HA using mesogun multineedle injector may be a safe and effective treatment for improving skin hydration.