Premium
Therapeutic implications of immunohistochemical expression pattern of the cancer stem cell marker (nestin) in basal and squamous cell carcinomas
Author(s) -
Rabea Ali R.,
Elshahid Ahmed R.,
Elhakim Mohamed S.,
Hashish Yahia H.,
Jafferany Mohammad,
Elsaie Mohamed L.
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13921
Subject(s) - nestin , immunohistochemistry , pathology , stem cell marker , cancer stem cell , basal cell carcinoma , medicine , stem cell , basal cell , pathological , cancer research , cancer , biology , neural stem cell , microbiology and biotechnology
Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. In the present study, we aimed to investigate the expression pattern and clinical significance of the stem cell marker nestin, in Squaous cell carcinoma (SCC) and basal cell carcinoma (BCC). The samples (23 cases of BCC and 22 cases of SCC) were immunohistochemically examined for the expression of nestin and its correlation with the corresponding clinical and pathological parameters. Nestin was expressed in four out of the 23 cases of BCC (17.4%) and was expressed in 10 out of the 22 cases of SCC (45.5%). Nestin expression between the two tumors was statistically significant ( P = .042). Although a direct relationship was found between the tumor grade and nestin expression, the results were statistically insignificant ( P = .495). The results of this study suggest that BCC and SCC may share some cellular origin but with different biologic behavior. The relation of nestin expression to the grade of SCC, although statistically insignificant, may suggest its role in predicting the biologic behavior of this tumor.