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Therapeutic implications of narrow band ultraviolet B on psoriasis severity and serum levels of acute phase reactants
Author(s) -
Nada Hesham A.,
Elshabrawy Mohamed M.,
Aly Doaa M.,
Jafferany Mohammad,
Elsaie Mohamed L.
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13856
Subject(s) - psoriasis , medicine , psoriasis area and severity index , fibrinogen , severity of illness , acute phase protein , ultraviolet b , gastroenterology , dermatology , ultraviolet therapy , correlation , inflammation , geometry , mathematics
Acute phase reactants (APR) are proteins that had been associated with psoriasis severity. We aimed to evaluate the association between psoriasis disease severity and some inflammatory markers as (CRP, ESR, and fibrinogen) before and after narrow band ultraviolet NB (NB‐UVB) therapy. The present study included 38 psoriatic patients and 38 controls of matching age and sex. The 38 included patients were divided according to their pretreatment PASI score into 2 subgroups: moderate 13 (34.2%) and severe 25 (65.8%). CRP, ESR, and fibrinogen levels were measured before and after NBUVB sessions for psoriatic patients and their levels were correlated to psoriasis area and severity index (PASI) improvements. PASI scores and laboratory values of APRs showed a significant difference before and after NBUVB sessions. PASI scores significantly correlated with CRP and FBG levels before and after treatment whereas no significant correlation was demonstrated between PASI and ESR levels before and after treatment. A combination of inflammatory markers and clinical assessment could be used in the formation of a new diagnostic tool to evaluate psoriasis severity and response to treatment.