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Combination of oral methotrexate and oral mini‐pulse dexamethasone vs either agent alone in vitiligo treatment with follow up by dermoscope
Author(s) -
ElGhareeb Mohamed Ibrahim,
Metwalli Mohamed,
AbdelMoneim Nehal
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13586
Subject(s) - medicine , vitiligo , methotrexate , dexamethasone , group b , gastroenterology , group a , dermatology
This study aimed to compare the efficacy and safety of oral methotrexate (MTX) and oral mini‐pulse (OMP) dexamethasone alone and in combination in the treatment of vitiligo. A total of 42 patients with vitiligo were included in the study. The patients were treated for three months and randomly assigned into three groups including 14 patients each: group A received oral MTX, group B received OMP dexamethasone, and group C received a combination of both. Follow‐up was performed using digital photographs, Vitiligo European Task Force score, and dermoscopy. Disease extension significantly decreased in group C compared with that in groups A ( P < .001) and B ( P < .05). The frequency of intralesional pigmentation significantly increased ( P < .05) in groups A and C and decreased ( P < .05) in group B posttreatment noted using a dermoscope. Moreover, the frequency of micro‐Koebner's phenomenon and starburst pattern significantly decreased ( P < .05) in groups B and C and that of tapioca sago in group C only posttreatment.