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Fluctuations in serum levels of adalimumab and infliximab in patients on stable treatment for psoriasis
Author(s) -
Poulsen Anne Sofie Konstantin,
Thomsen Simon Francis,
Vinkel Caroline,
Ghazanfar Misbah Noshela,
WulfJohansson Helle,
Bonne Rikke,
Larsen Rune
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13497
Subject(s) - medicine , adalimumab , psoriasis , infliximab , body mass index , drug , gastroenterology , serum concentration , dermatology , tumor necrosis factor alpha , pharmacology
Abstract Many patients with psoriasis fail to respond to biologic drugs either initially or lose response over time, the latter having predominantly been linked to low circulating drug levels. We examined how serum drug levels varied over three treatment cycles of stable maintenance therapy with either adalimumab or infliximab among a total of 28 patients with psoriasis (22 men, mean age 48.6 years, mean treatment time 6.2 years) and whether there was an association with various patient‐specific factors. The range for all concentrations was 1.1 to 24.3 μg/mL for adalimumab and 0.0 to 180.6 μg/mL for infliximab. There was a consistent inverse association between body mass index (BMI) and trough and maximum serum concentrations of adalimumab ( P < .05 for all comparisons) and a positive, less consistent, association between age and maximum serum concentration of infliximab ( P < .05 for both comparisons). Patient‐specific factors, such as BMI and age, can help predict fluctuations in serum concentrations of biologics used for psoriasis.