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Evaluation of 25‐hydroxy vitamin D levels and disease severity in patients with acne vulgaris
Author(s) -
Kemeriz Funda,
Tuncer Sibel Çiğdem,
Acar Emine Müge,
Tuğrul Burcu
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13393
Subject(s) - acne , medicine , vitamin d and neurology , etiology , vitamin , vitamin d deficiency , pathogenesis , gastroenterology , disease , severity of illness , endocrinology , dermatology
Acne vulgaris is a multifactorial skin disorder. Many etiological factors are speculated to contribute to the pathogenesis of acne, one of these is vitamin D deficiency. Previous studies reported contradictory results about serum 25 hydroxy vitamin D (25‐OH vitamin D) levels, its association with acne, some claimed that acne lesion might improve with vitamin D supplementation. We aimed to assess serum 25‐OH vitamin D levels in acne patients, identify their relation with disease severity in a larger study group. The study included 134 acne patients, 129 control s. Acne disease severity was identified with Global Acne Grading Scale (GAGS) scores. Serum 25‐OH vitamin D levels were measured in all groups. Serum 25‐OH vitamin D levels were significantly lower in acne patients than in controls ( P < .001). The prevalence of vitamin D deficiency was significantly higher in acne group than in control group (77.6% vs 63.9%; P = .041). There was a negative‐strong statistically significant correlation detected between serum 25‐OH vitamin D levels and GAGS scores in patient group ( P < .001; r = −.910). According to these results, we claim that evaluating serum 25‐OH vitamin D levels in acne patients, vitamin D supplementation as a treatment option may be a consideration for further studies.