A case of Jarisch–Herxheimer reaction in candidiasis treated with systemic fluconazole

Jarisch–Herxheimer reaction (JHR) is an acute and self‐limited condition, which commonly occurs after treatment for spirochetal infections. Probably, it corresponds to a transient immunological reaction to endotoxin‐like products released from the microorganism during the therapy. For this reason, JHR may be associated with many other infectious diseases besides syphilis. Here, we report a case of a patient affected by extended cutaneous candidiasis diagnosed by culture examination; a JHR occurred after an accidental overdose of oral fluconazole.