Premium
Levocetirizine for the treatment of itch in psoriasis patients: An open‐label pilot study in a real‐world setting
Author(s) -
Mueller Simon M.,
Navarini Alexander A.,
Goldust Mohamad,
Brandt Oliver,
Griffiths Christopher E. M.,
Kleyn Christine E.
Publication year - 2019
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13166
Subject(s) - medicine , levocetirizine , dermatology , psoriasis , open label , intensive care medicine , pharmacology , adverse effect
Itch is the most bothersome symptom in psoriasis, often leading to impaired quality of life. Treatment of psoriasis‐induced itch is frequently unsatisfactory as the various therapies employed have a delayed onset of effect. Histamine‐1 receptor (H1) antihistamines are not recommended in treatment guidelines as histamine is not considered a key mediator in psoriasis. However, patients using H1 antihistamines frequently report benefits in questionnaire‐based studies. To address these contradictions, we examined the short‐term effects of levocetirizine, a nonsedating H1 antihistamine, on psoriasis‐related itch and itch‐related quality of life. In this pilot study, patients with psoriasis‐related itch received levocetirizine 5–10 mg daily as a concomitant treatment for 5 days. Change of itch intensity as measured by hourly itch ratings and the change of itch‐related quality of life were measured at different time points. A total of 29 of 30 patients (96%) reported a decline in itch within 5 days. Mean itch reduction was 23% after Day 1 ( p = .005), 40% after Day 3 ( p < .001), and 41% after Day 5 ( p < .001). Furthermore, itch‐related quality of life also significantly improved after 5 days ( p < .001). Only 2 of 30 patients (6.7%) reported mild sleepiness. Levocetirizine 5–10 mg daily as an add‐on therapy seems to be an effective treatment to improve itch and itch‐related quality of life within only a few days.