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A first report of porphyria cutanea tarda successfully treated with glycyrrhizin
Author(s) -
Li Ying,
Yu Ning,
Han Dandan,
Ding Yangfeng,
Xu Yueming
Publication year - 2019
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.13014
Subject(s) - medicine , porphyria cutanea tarda , glycyrrhizin , gastroenterology , alkaline phosphatase , dermatology , porphyria , phlebotomy , enzyme , biochemistry , chemistry
Porphyria cutanea tarda (PCT) is a condition that affects liver and skin by reduction of hepatic uroporphyrinogen decarboxylase activity. It is characterized by blistering lesions, erosions and crusts on sun‐exposed areas. We report a 51‐year‐old male presenting with recurrent episodes of bullae, erosions, and crust on his neck and dorsum of the hands for 3 months. Aspartate aminotransferase, alanine aminotransferase, gamma‐glutamyl transferase, alkaline phosphatase, lactate dehydrogenase levels, as well as total plasma porphyrin and urinary uroporphyrin levels were elevated. Based on the clinical manifestations, the history and laboratory findings, a diagnosis of PCT was made. The cutaneous and biochemical abnormalities of the patient improved with therapy of glycyrrhizin.