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JAK/STAT pathway modulation: Does it work in dermatology?
Author(s) -
Gündüz Özgür
Publication year - 2019
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.12903
Subject(s) - janus kinase , stat protein , medicine , stat , jak stat signaling pathway , alopecia areata , psoriasis , signal transduction , atopic dermatitis , immunology , cancer research , microbiology and biotechnology , cytokine , tyrosine kinase , stat3 , biology
Janus kinase—signal transducer and activator of transcription (JAK/STAT)‐is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Several molecules that modulate—inhibit—this pathway are currently under investigation for the evaluation of their clinical use in dermatological diseases. A brief overview of the therapeutical use of JAK/STAT inhibitors in dermatology will be provided here.