Premium
Pemphigus vulgaris‐associated interstitial lung disease
Author(s) -
Bai YiXiu,
Chu JinGang,
Xiao Ting,
Chen HongDuo
Publication year - 2016
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.12342
Subject(s) - medicine , pemphigus vulgaris , interstitial lung disease , dermatology , bullous pemphigoid , rheumatoid arthritis , prednisone , autoantibody , dermatomyositis , discontinuation , immunology , gastroenterology , lung , antibody
Autoimmune bullous diseases (AIBDs)‐associated interstitial lung disease (ILD) is extremely rare. Pemphigus vulgaris (PV) is an intraepidermal autoimmune blistering disease caused by circulating autoantibodies against desmoglein. To date, PV‐associated ILD has rarely been reported in English literature. We report a rare association of PV and ILD. A 53‐year‐old Chinese female with PV for 8 months developed ILD after a relapse of PV for 2 months due to discontinuation of oral prednisone by herself. She was successfully treated by systemic methylprednisolone. Taken previously reported bullous pemphigoid‐associated ILD and linear IgA/IgG bullous dermatosis‐associated ILD together, in general, AIBDs‐associated ILD occurs when AIBDs relapse or are not controlled, responds well to systemic corticosteroids, and has a relatively better prognosis when compared with rheumatoid arthritis‐ or dermatomyositis‐associated ILD.