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Anti‐tumour necrosis factor treatment of severe psoriasis complicated by E pstein– B arr Virus hepatitis and subsequently by chronic hepatitis
Author(s) -
Cetkovska Petra,
Lomicova Iva,
Mukensnabl Petr,
Kroes Aloysius C.M.
Publication year - 2015
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.12271
Subject(s) - medicine , psoriasis , infliximab , psoriatic arthritis , adalimumab , hepatitis , dermatology , immunology , hepatitis a , tumor necrosis factor alpha
A case is described of severe acute hepatitis in 47‐year‐old woman with chronic psoriasis and psoriatic arthritis treated with infliximab. Although clinical, serological and laboratory results were compatible with acute EBV hepatitis, it was difficult to differentiate between EBV infection and other non‐infectious causes of hepatitis. The patient gradually developed chronic hepatitis with liver steatosis and efficient treatment with adalimumab had to be stopped. This case presents an uncommon complication that may arise from the use of biologic therapy and calls for caution in long‐term management of psoriatic patients with internal comorbidities.