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Drug fever as an adverse effect of acitretin in complicated psoriasis patient
Author(s) -
Rob Filip,
Fialová Jorga,
Brejchová Miroslava,
Džambová Martina,
Sečníková Zuzana,
Zelenková Darina,
Jiráková Anna,
Hercogová Jana
Publication year - 2015
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.12263
Subject(s) - acitretin , medicine , psoriasis , discontinuation , dermatology , adverse effect , drug , antibiotics , plaque psoriasis , surgery , pharmacology , biology , microbiology and biotechnology
We present a case of a 63‐year old man with severe chronic plaque psoriasis and a recent history of lung cancer, wherein fever appeared suddenly after initiation of treatment with low dose acitretin. Tumor recurrence or infection was not found during extensive examinations, nevertheless the patient was empirically treated with broad‐spectrum antibiotics without any effect on fever. Immediately after discontinuation of acitretin therapy, the fever disappeared. The patient was followed for next 2 years, during this period similar problems did not reappear, although there has been a relapse of psoriasis and the patient was switched later on biological treatment.