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The efficacy of minocycline in inflammatory dermatoses: a case of prurigo pigmentosa of prepubescent onset in W estern world
Author(s) -
Gironi Laura Cristina,
Farinelli Pamela,
Giacalone Angela,
Colombo Enrico
Publication year - 2015
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.12216
Subject(s) - medicine , minocycline , dermatology , hyperpigmentation , antibiotics , microbiology and biotechnology , biology
We present a 21‐year‐old Italian girl with an 8‐year history of missed diagnosed prurigo pigmentosa ( PP ) successfully treated with short monotherapy with minocycline. PP is an inflammatory disease characterized by recurrent pruritic erythematous papules followed by reticular hyperpigmentation usually located on the trunk. About 300 cases of PP have been described mainly in J apan, whereas only few cases have been reported in Italy. This report shows that minocycline is rapidly effective probably through its ability to scavenge reactive oxygen species and to inhibit the chemotaxis and neutrophil function. Other than its ethnic rarity, this case is very interesting because it is the third case of PP in C aucasian patient with prepubescent onset.