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Triple combination treatment with fractional CO 2 laser plus topical betamethasone solution and narrowband ultraviolet B for refractory vitiligo: a prospective, randomized half‐body, comparative study
Author(s) -
Li Lu,
Wu Yan,
Li Li,
Sun Yan,
Qiu Li,
Gao XingHua,
Chen HongDuo
Publication year - 2015
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.12202
Subject(s) - medicine , vitiligo , refractory (planetary science) , betamethasone , dermatology , carbon dioxide laser , adverse effect , surgery , laser , optics , physics , astrobiology , laser surgery
Vitiligo on extremities and/or bony prominences is very resistant to treatment. Twenty‐five patients with symmetrical and stable vitiligo on extremities and/or bony prominences were enrolled. The treatment side received fractional carbon dioxide laser followed by topical compound betamethasone solution and narrowband ultraviolet B phototherapy. The control side received laser treatment plus phototherapy. The result of treatment side showed that 44% patients achieved over 50% re‐pigmentation and patient satisfaction score was 5.12 ± 3.23, higher than those of control ( p < 0.05). Adverse events were slight and tolerable. The triple combination treatment could be used as an alternative modality for refractory vitiligo.