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Both low‐dose arotinoid ethylester and acitretin are effective in the treatment of familial erythrokeratodermia variabilis
Author(s) -
Zhang Li,
Hong Yuxiao,
Zheng Song,
Huo Wei,
Qi Ruiqun,
Geng Long,
Chen HongDuo,
Gao XingHua
Publication year - 2014
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.12127
Subject(s) - acitretin , medicine , dermatology , pharmacology , psoriasis
We previously reported a large C hinese pedigree of erythrokeratodermia variabilis ( EKV ). A unique feature was that some of the affected members experienced transitory pustules on the border of classic lesions. Here we prescribed oral arotinoid ethylester and acitretin to two of the affected members in the pedigree, at starting dosage of 0.03 mg/day for arotinoid ethylester and 30 mg/day for acitretin, maintenance dosage of 0.03 mg every other day and 20 mg/day, respectively. Both patients reached complete clearance of the lesions during the treatment period. Side effect was negligible for the case on arotinoid ethylester. The patient on acitretin experienced elevated level of serum triglyceride and alanine aminotransferase that restrained further use.