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Effect of liraglutide on food consumption, appetite sensations and eating behaviours in overweight people with type 1 diabetes
Author(s) -
Dubé MarieChristine,
D'Amours Martin,
Weisnagel S. John
Publication year - 2020
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.14050
Subject(s) - liraglutide , appetite , overweight , medicine , crossover study , placebo , type 2 diabetes , obesity , endocrinology , insulin , diabetes mellitus , alternative medicine , pathology
Aims To investigate the effects of 24 weeks of treatment with liraglutide added to basal/bolus insulin on energy intake, appetite sensations and eating behaviours in overweight/obese participants with type 1 diabetes (T1D). Methods In a double‐blinded crossover fashion, 15 participants were randomly assigned (1:1) to receive placebo or liraglutide for 24 weeks including a 1‐month titration period from 0.6 to 1.2 to 1.8 mg, in addition to their insulin. The treatment was followed by a 1‐month wash‐out period. Participants were then assigned to the other treatment for another 24 weeks. Food intake was measured, visual analogue scales and Three‐Factor Eating Questionnaires were completed. Paired rank tests were used to compare the variables. Results When treated with liraglutide, participants modified their ad libitum food consumption with decreased total intake and % fat and increased carbohydrates. Their appetite sensations were modified: fasting desire to eat, hunger and prospective food consumption were significantly reduced. The sensation of fullness was prolonged for a few hours after a standardized breakfast. Restraint and disinhibition were significantly reduced by liraglutide. Conclusions In this randomized clinical trial, the addition of liraglutide to basal/bolus insulin therapy for 24 weeks in overweight/obese individuals with T1D significantly improved their food consumption, appetite sensations and eating behaviours.