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Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes
Author(s) -
Christensen Regitse H.,
Hansen Christian S.,
Scholten Bernt Johan,
Jensen Magnus T.,
Pedersen Bente K.,
Schnohr Peter,
Vilsbøll Tina,
Rossing Peter,
Jørgensen Peter G.
Publication year - 2019
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13758
Subject(s) - medicine , cardiology , type 2 diabetes , diastole , speckle tracking echocardiography , epicardial adipose tissue , adipose tissue , diabetes mellitus , diabetic cardiomyopathy , tissue doppler echocardiography , doppler imaging , pericardium , epicardial fat , endocrinology , diastolic function , ejection fraction , heart failure , cardiomyopathy , blood pressure
The aim of this study was to investigate the association of epicardial (EAT) and pericardial (PAT) adipose tissues with myocardial function in type 2 diabetes (T2D). EAT and PAT were measured by ultrasound in 770 patients with T2D and 234 age‐ and sex‐matched non‐diabetic controls. Echocardiography was performed, including tissue Doppler imaging and 2D speckle tracking. Patients with T2D versus controls had increased EAT (4.6 ± 1.8 mm vs. 3.4 ± 1.2 mm, P < 0.0001) and PAT (6.3 ± 2.8 mm vs. 5.3 ± 2.4 mm, P < 0.0001). EAT and PAT were associated with structural cardiac measures both in T2D patients and controls (all P < 0.043), but only in T2D patients with functional measures: PAT was associated with impaired global longitudinal strain [beta coefficient (SE)] [0.11% (0.04), P = 0.002], while EAT was associated with reduced diastolic function by lateral early diastolic myocardial velocity (e’ lat ) [−0.31 (0.05) cm/s, P = 0.001], mitral inflow velocities: peak early (E)/peak atrial (A) ratio [−0.02 (0.01), P = 0.001] and lateral E/e’ lat [0.36 (0.10), P < 0.001]. However, no interaction was found between diabetes status and PAT ( P = 0.75) or EAT ( P = 0.45). Adipose tissue in intimate relation to the myocardium is higher in patients with T2D versus controls and is associated with functional myocardial measures in T2D.