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The importance of dyslipidaemia in the pathogenesis of cardiovascular disease in people with diabetes
Author(s) -
Gonna Hanney,
Ray Kausik K.
Publication year - 2019
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13691
Subject(s) - dyslipidemia , diabetes mellitus , medicine , disease , epidemiology , pathogenesis , etiology , population , pathophysiology , type 2 diabetes , bioinformatics , endocrinology , biology , environmental health
Atherosclerotic cardiovascular events are the leading cause of mortality and morbidity in those with diabetes. A key contributor to the development of atherosclerosis in this population is the presence of a particularly atherogenic lipid profile often referred to as ‘Diabetic Dyslipidemia’. This profile is characterized by elevated triglycerides, triglyceride‐rich lipoproteins, small dense LDL particles, and reduced HDL levels. This article reviews the underlying aetiology and pathophysiology of this dyslipidaemia and atherosclerosis in those with diabetes, provides insights from epidemiological and genetic studies, and current cardiovascular risk reducing interventions including novel therapies such as PCSK‐9 inhibitors.