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Intranasal glucagon acutely increases energy expenditure without inducing hyperglycaemia in overweight/obese adults
Author(s) -
Stahel Priska,
Lee So Jeong,
Sud Shawn K.,
Floh Alejandro,
Dash Satya
Publication year - 2019
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13661
Subject(s) - overweight , medicine , resting energy expenditure , crossover study , appetite , endocrinology , glucagon , placebo , nasal administration , insulin , adverse effect , energy expenditure , obesity , pharmacology , alternative medicine , pathology
Aim To assess the acute effects of 0.7 mg intranasal glucagon (ING) vs intranasal placebo (INP) on food intake and resting energy expenditure (REE). Methods A single‐blind, crossover study was conducted in 19 overweight/obese adults (15 men, 4 women). REE was assessed by indirect calorimetry over 90 minutes, after which appetite was assessed using a visual analogue scale, and ad libitum caloric intake was assessed. Plasma samples were obtained at baseline and at 15‐minute intervals post‐treatment up to 90 minutes. Results ING increased total REE (INP 61.5 ± 1.2 kcal vs ING 69.4 ± 1.2 kcal; P = 0.027). There were no between‐treatment differences in blood glucose, food intake and appetite. There were no adverse effects. Conclusion ING acutely increases REE without increasing plasma glucose. Longer term studies with multiple daily dosing will establish whether this affects body weight.