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Dynamic changes in insulin and glucagon during disease progression in rhesus monkeys with obesity‐related type 2 diabetes mellitus
Author(s) -
Wang Can,
Xiao Yao,
Wang Jue,
Hou Ning,
Cui Weiyi,
Hu Xiaomin,
Zeng Fanxin,
Yuan Ye,
Ma Dongwei,
Sun Xueting,
Zhang Yan,
Zheng Wen,
Liu Yuli,
Shang Haibao,
Chen Liangyi,
Xiao RuiPing,
Zhang Xiuqin
Publication year - 2019
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13624
Subject(s) - medicine , insulin , endocrinology , type 2 diabetes mellitus , obesity , glucagon , diabetes mellitus
Aims To investigate the progression of obesity‐related type 2 diabetes mellitus (T2DM) in rhesus monkeys, especially dynamic changes in insulin and glucagon. Materials and methods We followed a cohort of 52 rhesus monkeys for 7 years throughout the progression of obesity‐related T2DM. Intravenous glucose tolerance tests were performed every 6 months to evaluate dynamic changes in glucose, insulin and glucagon levels. Results Obesity in rhesus monkeys increased the overall mortality and T2DM morbidity. During the progression of T2DM, glucagon remained consistently elevated, while insulin initially increased in compensation but then dropped to below normal levels when the monkeys developed overt T2DM. After a glucose challenge, both the first and second phases of insulin secretion increased during the early stage of T2DM; in later stages the first phase was delayed and the second phase was diminished. Conclusion Our findings showed that, beside the decreased insulin level, hyperglucagonaemia also plays an important role in the development of T2DM.