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Aims  To compare the time spent in specified glycaemic ranges in people with type 1 diabetes (T1D) during 5 consecutive days of moderate‐intensity exercise while on either 100% or 75% of their usual insulin degludec (IDeg) dose.    Materials and Methods  Nine participants with T1D (four women, mean age 32.1 ± 9.0 years, body mass index 25.5 ± 3.8 kg/m 2 , glycated haemoglobin 55 ± 7 mmol/mol (7.2% ± 0.6%) on IDeg were enrolled in the trial. Three days before the first exercise period, participants were randomized to either 100% or 75% of their usual IDeg dose. Participants exercised on a cycle ergometer for 55 minutes at a moderate intensity for 5 consecutive days. After a 4‐week wash‐out period, participants performed the last exercise period for 5 consecutive days with the alternate IDeg dose. Time spent in specified glycaemic ranges, area under the curve and numbers of hypoglycaemic events were compared for the 5 days on each treatment allocation using a paired Students'  t  test, Wilcoxon matched‐pairs signed‐rank test and two‐way ANOVA.    Results  Time spent in euglycaemia over 5 days was greater for the 75% IDeg dose versus the 100% IDeg dose (4008 ± 938 minutes vs. 3566 ± 856 minutes;  P  = 0.04). Numbers of hypoglycaemic events ( P  = 0.91) and time spent in hypoglycaemia ( P  = 0.07) or hyperglycaemia ( P  = 0.38) was similar for both dosing schemes.    Conclusions  A 25% reduction in usual IDeg dose around regular exercise led to more time spent in euglycaemia, with small effects on time spent in hypo‐ and hyperglycaemia.

diabetes, obesity and metabolism

Reduction in insulin degludec dosing for multiple exercise sessions improves time spent in euglycaemia in people with type 1 diabetes: A randomized crossover trial