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Association of abdominal muscle composition with prediabetes and diabetes: The CARDIA study
Author(s) -
Granados Andrea,
Gebremariam Achamyeleh,
Gidding Samuel S.,
Terry James G.,
Carr John Jeffrey,
Steffen Lyn M.,
Jacobs David R.,
Lee Joyce M.
Publication year - 2019
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13513
Subject(s) - prediabetes , medicine , diabetes mellitus , adipose tissue , quartile , cardiorespiratory fitness , type 2 diabetes , intra abdominal fat , cardiology , endocrinology , insulin resistance , visceral fat , confidence interval
Aim To evaluate the relationship of abdominal muscle lean tissue and adipose tissue volumes with prediabetes and diabetes. Research Design and Methods We measured abdominal muscle composition in 3170 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent computed tomography (CT) at Year 25 of follow‐up (ages, 43‐55 years). Multinomial regression analysis was used to evaluate the associations of CT‐measured intermuscular adipose tissue (IMAT), lean muscle tissue (lean) and visceral adipose tissue (VAT) volumes with diabetes at any point during the CARDIA study, newly detected prediabetes, prior history of prediabetes, and normal glucose tolerance. Models were adjusted for potential confounding factors: age, sex, race, height, smoking status, hypertension, hyperlipidaemia, cardiorespiratory fitness and study centre. Results Higher IMAT, lean and VAT volumes were all separately associated with a higher prevalence of prediabetes and diabetes. Inclusion of VAT volume in models with both IMAT volume and lean volume attenuated the association of IMAT with both prediabetes and diabetes, but higher lean volume retained its association with prediabetes and diabetes. Individuals in the highest IMAT quartile, coupled with VAT in its lower three quartiles, had a higher prevalence of diabetes, but not of prediabetes, than those with both IMAT and VAT in their respective lower three quartiles. Adjusting for cardiorespiratory fitness did not substantially change the findings. Conclusion Higher IMAT volume was associated with a higher prevalence of diabetes even after adjustment for VAT volume. However, further study is warranted to understand the complicated relationship between abdominal muscle and adipose tissues.