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Effectiveness of dapagliflozin versus comparators on renal endpoints in the real world: A multicentre retrospective study
Author(s) -
Fadini Gian Paolo,
Solini Anna,
Manca Maria Laura,
Penno Giuseppe,
Gatti Adriano,
Anichini Roberto,
Del Prato Stefano,
Avogaro Angelo
Publication year - 2019
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13508
Subject(s) - dapagliflozin , medicine , renal function , type 2 diabetes , interquartile range , diabetes mellitus , glycemic , urology , gliclazide , retrospective cohort study , creatinine , endocrinology
Aim To evaluate the changes in renal endpoints in type 2 diabetes patients treated with dapagliflozin versus other glucose‐lowering medications in routine clinical practice. Materials and Methods DARWIN‐T2D was a retrospective study conducted at 46 outpatient diabetes clinics in Italy. An automated software collected data on 17 285 patients who received dapagliflozin, glucagon‐like peptide‐1 receptor agonists, dipeptidyl peptidase‐4 inhibitors, or gliclazide, 6751 of whom had a follow‐up visit. We analysed changes in albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR). Results Patients who received dapagliflozin ( n = 473) were younger, more obese, and had a poorer glucose control than those who received a comparator ( n = 2973). After ~6 months, median (interquartile range) AER declined by 37%, from 19.5 (7.5–78.2) to 13.2 (6.5–45.0) mg/g ( P < 0.0001) in the dapagliflozin group and did not change in the comparator group. After adjusting for confounders, therapy with dapagliflozin versus comparators was associated with an AER reduction of 26.4 ± 13.1 mg/g ( P = 0.045), and eGFR (mL/min/1.73 m 2 ) diminished by 1.1 ± 0.5 ( P = 0.049) in the dapagliflozin group and by 0.6 ± 9.1 ( P = 0.002) in the comparator group ( P = 0.35 between groups). No patient treated with dapagliflozin versus four patients treated with comparators experienced a doubling of serum creatinine. Conclusions The antiproteinuric effect of dapagliflozin is confirmed here for the first time by real‐world data. Despite a mild decline in eGFR, there was no evidence of clinically relevant worsening in renal function.