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The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans
Author(s) -
IzziEngbeaya Chioma,
Comninos Alexander N.,
Clarke Sophie A.,
Jomard Anne,
Yang Lisa,
Jones Sophie,
Abbara Ali,
Narayanaswamy Shakunthala,
Eng Pei Chia,
Papadopoulou Deborah,
Prague Julia K.,
Bech Paul,
Godsland Ian F.,
Bassett Paul,
Sands Caroline,
Camuzeaux Stephane,
GomezRomero Maria,
Pearce Jake T. M.,
Lewis Matthew R.,
Holmes Elaine,
Nicholson Jeremy K.,
Tan Tricia,
Ratnasabapathy Risheka,
Hu Ming,
Carrat Gaelle,
Piemonti Lorenzo,
Bugliani Marco,
Marchetti Piero,
Johnson Paul R.,
Hughes Stephen J.,
James Shapiro A. M.,
Rutter Guy A.,
Dhillo Waljit S.
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13460
Subject(s) - kisspeptin , endocrinology , medicine , appetite , insulin , hormone , secretion , biology , carbohydrate metabolism
Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and appetite in humans. Materials and methods In 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m −2 ), we compared the effects of 1 nmol kg −1 h −1 kisspeptin versus vehicle administration on glucose‐stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucose‐stimulated insulin secretion in vitro in human pancreatic islets and a human β‐cell line (EndoC‐βH1 cells). Results Kisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose‐stimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men. Conclusions Collectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin‐based therapies for reproductive and potentially metabolic conditions.