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Comparison of pancreatic volume and fat amount linked with glucose homeostasis between healthy Caucasians and Koreans
Author(s) -
Roh Eun,
Kim Kyoung M.,
Park Kyeong S.,
Kim Yoon J.,
Chun Eun J.,
Choi Sung H.,
Park Kyong S.,
Jang Hak C.,
Lim Soo
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13447
Subject(s) - medicine , body mass index , insulin resistance , pancreas , endocrinology , diabetes mellitus , glucose homeostasis , population , physiology , gastroenterology , environmental health
Aim To compare pancreatic volume and fat amount, and their associations with glucose homeostasis, in a Korean and a white population. Materials and methods In 43 healthy Korean and 43 healthy white people, matched for age (±3 years) and body mass index (BMI; ±1 kg/m 2 ), we measured pancreatic volume and fat amount in the pancreas and abdomen using computed tomography. Pancreatic β‐cell function and insulin resistance were estimated according to biochemical characteristics and a 75‐g oral glucose tolerance test. Body composition and resting energy expenditure (REE) were examined using bioimpedance and indirect calorimetry, respectively. Results The mean ±SD age of the participants was 29.9 ± 5.9 years and 30.0 ± 5.2 years, and BMI was 24.0 ±3.7 and 24.1 ±3.2 kg/m 2 in the white participants and the Korean participants, respectively. Pancreatic volume in the white participants was greater than that in Korean participants (77.8 ±11.6 vs 68.2 ±12.1 cm 3 ; P < .001). Pancreatic fat content in Korean participants was 22.8% higher than in white participants ( P = .051). Insulinogenic index, disposition index, muscle mass and REE were significantly lower in Korean participants. Pancreatic volume was positively associated with indices linked to β‐cell function; fat content in the pancreas was negatively associated with such indices, and positively with insulin resistance after adjusting for relevant variables including REE. Conclusions A smaller pancreas and higher fat deposition might be crucial determinants of vulnerability to diabetes in Korean people compared with white people with similar BMI and body fat levels.