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Role of ghrelin in pancreatic development and function
Author(s) -
Napolitano Tiziana,
Silvano Serena,
Vieira Andhira,
Balaji Shruti,
GarridoUtrilla Anna,
Friano Marika E.,
Atlija Josipa,
Collombat Patrick
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13385
Subject(s) - ghrelin , endocrinology , medicine , anabolism , energy homeostasis , enteroendocrine cell , endocrine system , pancreas , biology , energy expenditure , appetite , homeostasis , hormone , secretion , obesity
Ghrelin is a gastric peptide with anabolic functions. It acutely stimulates growth hormone (GH) secretion from the anterior pituitary glands and modulates hypothalamic circuits that control food intake and energy expenditure. Besides its central activity, ghrelin is also involved in the regulation of pancreatic development and physiology. Particularly, several studies highlighted the ability of ghrelin to sustain β‐cell viability and proliferation. Furthermore, ghrelin seems to exert inhibitory effects on pancreatic acinar and endocrine secretory functions. Due to its pleiotropic activity on energy metabolism, ghrelin has become a topic of great interest for experimental research focused on type II diabetes and obesity. The aim of this review is to illustrate the complex and not fully understood interplay between ghrelin, pancreas and glucose homeostasis.