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Hypoglycaemia incidence and recovery during home use of hybrid closed‐loop insulin delivery in adults with type 1 diabetes
Author(s) -
Ruan Yue,
Bally Lia,
Thabit Hood,
Leelarathna Lalantha,
Hartnell Sara,
Tauschmann Martin,
Wilinska Malgorzata E.,
Evans Mark L.,
Mader Julia K.,
Kojzar Harald,
Dellweg Sibylle,
Benesch Carsten,
Arnolds Sabine,
Pieber Thomas R.,
Hovorka Roman
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13304
Subject(s) - medicine , insulin delivery , insulin , type 1 diabetes , insulin pump , incidence (geometry) , diabetes mellitus , continuous glucose monitoring , hypoglycemia , closed loop , crossover study , endocrinology , mathematics , geometry , alternative medicine , pathology , control engineering , engineering , placebo
Glucose excursion was assessed prior to and post hypoglycaemia to increase understanding of hypoglycaemia incidence and recovery during hybrid closed‐loop insulin delivery. We retrospectively analysed data from 60 adults with type 1 diabetes who received, in a crossover randomized design, day‐and‐night hybrid closed‐loop insulin delivery and insulin pump therapy, the latter with or without real‐time continuous glucose monitoring. Over 4‐week study periods, we identified hypoglycaemic episodes, defined as sensor glucose <3.0 mmol/L, and analysed sensor glucose relative to the onset of hypoglycaemia. We identified 377 hypoglycaemic episodes during hybrid closed‐loop intervention vs 662 during control intervention ( P < .001), with a predominant reduction of nocturnal hypoglycaemia. The slope of sensor glucose prior to hypoglycaemia was steeper during closed‐loop intervention than during control intervention ( P < .01), while insulin delivery was reduced ( P < .01). During both day and night, participants recovered from hypoglycaemia faster when treated by closed‐loop intervention. At 120 minutes post hypoglycaemia, sensor glucose levels were higher during closed‐loop intervention compared to the control period ( P < .05). In conclusion, closed‐loop intervention reduces the risk of hypoglycaemia, particularly overnight, with swift recovery from hypoglycaemia leading to higher 2‐hour post‐hypoglycaemia glucose levels.