Premium
Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery‐induced weight loss
Author(s) -
Dadson Prince,
Hannukainen Jarna C.,
Din Mueez U,
Lahesmaa Minna,
Kalliokoski Kari K.,
Iozzo Patricia,
Pihlajamäki Jussi,
Karlsson Henry K.,
Parkkola Riitta,
Salminen Paulina,
Virtanen Kirsi A.,
Nuutila Pirjo
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13233
Subject(s) - medicine , adipose tissue , triglyceride , radiodensity , obesity , nefa , hounsfield scale , lipid metabolism , weight loss , endocrinology , surgery , nuclear medicine , cholesterol , computed tomography , radiography , insulin
Objective We aimed to investigate the effect of bariatric surgery on lipid metabolism in supraclavicular brown adipose tissue in morbidly obese women. We hypothesized that lipid metabolism improves after surgery‐induced weight loss. Materials and methods A total of 23 morbidly obese women (BMI, 42.1 ± 4.2 kg/m 2 ; age, 43.8 ± 9.8 years) were assessed before and 6 months after bariatric surgery and 15 age‐ and sex‐matched controls (22.6 ± 2.8 kg/m 2 ) were assessed once. In the supraclavicular fat depot, fractional (FUR) and NEFA uptake rates were measured with 18 F‐FTHA‐PET. We assessed tissue morphology (triglyceride content) using computed tomography (CT)‐radiodensity (in Hounsfield Units[HU]) and the proportion of fat with high density (sBAT [%]) in the entire supraclavicular fat depot. Results The supraclavicular fractional uptake rate was lower in obese women compared to controls (0.0055 ± 0.0035 vs 0.0161 ± 0.0177 1/min, P = .001). Both FUR (to 0.0074 ± 0.0035 1/min, P = .01) and NEFA uptake rates (to 0.50 ± 0.50 μmol/100 g/min, P = .001) increased after surgery. Compared to controls, obese women had lower CT‐radiodensity (−101.2 ± 10.1 vs −82.5 ± 5.8 HU, P < .001) and sBAT (43.4 ± 8.4% vs 64.5 ± 12.4%, P < .001). After surgery, CT‐radiodensity increased (to −82.5 ± 9.6 HU, P < .001), signifying decreased triglyceride content and sBAT improved (to 58.0 ± 10.7%, P < .001), indicating an increased proportion of brown fat. The change in tissue morphology, reflected as increase in CT‐radiodensity and sBAT (%), was associated with a decrease in adiposity indices and an increase in whole‐body insulin sensitivity. Conclusions A decrease in triglyceride content, coupled with the increased proportion of brown adipose tissue in the supraclavicular fat depot, may play a role in the improvement of whole‐body insulin sensitivity observed in morbidly obese women after surgery‐induced weight loss.