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One‐year weight losses in the Tianjin Gestational Diabetes Mellitus Prevention Programme: A randomized clinical trial
Author(s) -
Liu Huikun,
Wang Leishen,
Zhang Shuang,
Leng Junhong,
Li Nan,
Li Weiqin,
Wang Jing,
Tian Huiguang,
Qi Lu,
Yang Xilin,
Yu Zhijie,
Tuomilehto Jaakko,
Hu Gang
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13225
Subject(s) - medicine , weight loss , overweight , gestational diabetes , randomized controlled trial , waist , obesity , physical therapy , body mass index , weight management , diabetes mellitus , pregnancy , gestation , endocrinology , biology , genetics
Aims To report the weight loss findings after the first year of a lifestyle intervention trial among women with gestational diabetes mellitus (GDM). Methods A total of 1180 women with GDM were randomly assigned (1:1) to receive a 4‐year lifestyle intervention (intervention group, n = 586) or standard care (control group, n = 594) between August 2009 and July 2011. Major elements of the intervention included 6 face‐to‐face sessions with study dieticians and two telephone calls in the first year, and two individual sessions and two telephone calls in each subsequent year. Results Among 79% of participants who completed the year 1 trial, mean weight loss was 0.82 kg (1.12% of initial weight) in the intervention group and 0.09 kg (0.03% of initial weight) in the control group ( P = .001). In a prespecified subgroup analysis of people who completed the trial, weight loss was more pronounced in women who were overweight (body mass index ≥24 kg/m 2 ) at baseline: mean weight loss 2.01 kg (2.87% of initial weight) in the intervention group and 0.44 kg (0.52% of initial weight) in the control group ( P < .001). Compared with those in the control group, women in the intervention group had a greater decrease in waist circumference (1.76 cm vs 0.73 cm; P = .003) and body fat (0.50% vs 0.05% increase; P = .001). Conclusion The 1‐year lifestyle intervention led to significant weight losses after delivery in women who had GDM, and the effect was more pronounced in women who were overweight at baseline.

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