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A review of GLP‐1 receptor agonists: Evolution and advancement, through the lens of randomised controlled trials
Author(s) -
Aroda Vanita R.
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13162
Subject(s) - medicine , tolerability , hypoglycemia , glycemic , clinical trial , intensive care medicine , type 2 diabetes , diabetes mellitus , randomized controlled trial , bioinformatics , adverse effect , endocrinology , biology
Aims To review the evolution and advancement of GLP‐1 receptor agonist (GLP‐1RA) therapy, through the lens of randomised controlled trials, from differentiating characteristics, efficacy, safety, tolerability, and cardiovascular outcomes, to evidence gaps and next steps. Methods Clinical review of published phase 3 or later RCT data studying efficacy, safety, and outcomes of approved GLP‐1 RA therapies. Results Through a wealth of studies, including both placebo‐controlled and active‐controlled studies, GLP‐1 RAs have demonstrated high glycemic efficacy and ability to facilitate weight loss, with minimal risk of hypoglycemia, potential to restore beta cell function, and evidence for improved cardiovascular outcomes in those at risk. Conclusions Over a decade of clinical studies have established the unique contributions of GLP‐1 RAs in the treatment of diabetes. Individual differences between the different GLP‐1 RAs, in delivery, pharmacokinetic and clinical effects, exist, allowing for tailored approaches to clinical care. The strength of evidence generated through RCTs, both short‐term and long‐term studies, will continue to evolve and inform our current paradigms in diabetes care.