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Preoperative weight loss with glucagon‐like peptide‐1 receptor agonist treatment predicts greater weight loss achieved by the combination of medical weight management and bariatric surgery in patients with type 2 diabetes: A longitudinal analysis
Author(s) -
Tang Tien,
Abbott Sally,
le Roux Carel W.,
Wilson Violet,
Singhal Rishi,
Bellary Srikanth,
Tahrani Abd A.
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13131
Subject(s) - weight loss , medicine , interquartile range , surgery , type 2 diabetes , retrospective cohort study , glucagon like peptide 1 receptor , agonist , weight management , obesity , diabetes mellitus , gastroenterology , endocrinology , receptor
We examined the relationship between weight changes after preoperative glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) treatment and weight changes from the start of medical weight management (MWM) until 12 months after bariatric surgery in patients with type 2 diabetes in a retrospective cohort study. A total of 45 patients (64.4% women, median [interquartile range] age 49 [45‐60] years) were included. The median (interquartile range) weight loss from start of MWM until 12 months post‐surgery was 17.9% (13.0%‐29.3%). GLP‐1RA treatment during MWM resulted in 5.0% (1.9%‐7.7%) weight loss. Weight loss during GLP‐1RA treatment predicted weight loss from the start of MWM until 12 months post‐surgery, but not postoperative weight loss after adjustment. The proportion of weight loss from start of MWM to 12 months post‐surgery attributed to GLP‐1RA treatment was negatively associated with that attributed to surgery, after adjustment. In conclusion, weight change after GLP‐1RA treatment predicted the weight loss achieved by a combination of MWM and bariatric surgery, but not weight loss induced by surgery only. Failure to lose weight after GLP‐1RA treatment should not be considered a barrier to undergoing bariatric surgery.