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Development of a cardiovascular diseases risk prediction model and tools for C hinese patients with type 2 diabetes mellitus: A population‐based retrospective cohort study
Author(s) -
Wan Eric Yuk Fai,
Fong Daniel Yee Tak,
Fung Colman Siu Cheung,
Yu Esther Yee Tak,
Chin Weng Yee,
Chan Anca Ka Chun,
Lam Cindy Lo Kuen
Publication year - 2018
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13066
Subject(s) - medicine , retrospective cohort study , cohort , renal function , diabetes mellitus , body mass index , proportional hazards model , cohort study , population , stepwise regression , type 2 diabetes mellitus , endocrinology , environmental health
Aims Evidence‐based cardiovascular diseases (CVD) risk prediction models and tools specific for Chinese patients with type 2 diabetes mellitus (T2DM) are currently unavailable. This study aimed to develop and validate a CVD risk prediction model for Chinese T2DM patients. Methods A retrospective cohort study was conducted with 137 935 Chinese patients aged 18 to 79 years with T2DM and without prior history of CVD, who had received public primary care services between January 1, 2010 and December 31, 2010. Using the derivation cohort over a median follow‐up of 5 years, the interaction effect between predictors and age were derived using Cox proportional hazards regression with a forward stepwise approach. Harrell's C statistic and calibration plot were used on the validation cohort to assess the discrimination and calibration of the models. The web calculator and chart were developed based on the developed models. Results For both genders, predictors for higher risk of CVD were older age, smoking, longer diabetes duration, usage of anti‐hypertensive drug and insulin, higher body mass index, haemoglobin A1c (HbA1c), systolic and diastolic blood pressure, a total cholesterol to high‐density lipoprotein‐cholesterol (TC/HDL‐C) ratio and urine albumin to creatinine ratio, and lower estimated glomerular filtration rate. Interaction factors with age demonstrated a greater weighting of TC/HDL‐C ratio in both younger females and males, and smoking status and HbA1c in younger males. Conclusion The developed models, translated into a web calculator and color‐coded chart, served as evidence‐based visual aids that facilitate clinicians to estimate quickly the 5‐year CVD risk for Chinese T2DM patients and to guide intervention.