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Metabolomics applied to islet nutrient sensing mechanisms
Author(s) -
Jensen Mette V.,
Gooding Jessica R.,
Ferdaoussi Mourad,
Dai XiaoQing,
Peterson Brett S.,
MacDonald Patrick E.,
Newgard Christopher B.
Publication year - 2017
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.13010
Subject(s) - metabolomics , islet , insulin , secretion , computational biology , biology , bioinformatics , chemistry , computer science , microbiology and biotechnology , biochemistry , endocrinology
After multiple decades of investigation, the precise mechanisms involved in fuel‐stimulated insulin secretion are still being revealed. One avenue for gaining deeper knowledge is to apply emergent tools of “metabolomics,” involving mass spectrometry and nuclear magnetic resonance‐based profiling of islet cells in their fuel‐stimulated compared with basal states. The current article summarizes recent insights gained from application of metabolomics tools to the specific process of glucose‐stimulated insulin secretion, revealing 2 new mechanisms that may provide targets for improving insulin secretion in diabetes.