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Non‐alcoholic fatty liver disease ( NAFLD ) prevalence and its metabolic associations in patients with type 1 diabetes and type 2 diabetes
Author(s) -
Cusi Kenneth,
Sanyal Arun J.,
Zhang Shuyu,
Hartman Mark L.,
BueValleskey Juliana M.,
Hoogwerf Byron J.,
Haupt Axel
Publication year - 2017
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12973
Subject(s) - medicine , fatty liver , type 2 diabetes , insulin resistance , insulin , diabetes mellitus , endocrinology , type 1 diabetes , type 2 diabetes mellitus , gastroenterology , disease
We investigated non‐alcoholic fatty liver disease ( NAFLD ) prevalence and its metabolic associations in patients with type 1 diabetes ( T1D ), and in insulin‐naïve and insulin‐treated patients with type 2 diabetes ( T2D ). Baseline data from patients who had liver fat content ( LFC ) evaluated by magnetic resonance imaging in four phase 3 studies of basal insulin peglispro ( BIL ) were analysed. Associations of NAFLD with clinical characteristics, glycaemic control and diabetes therapy were evaluated. The prevalence of NAFLD (defined as LFC ≥ 6%) was low in T1D (8.8%) but high in T2D , with greater prevalence in insulin‐naïve (75.6%) vs insulin‐treated (61.7%) T2D patients. LFC (mean ± SD ) was higher in T2D patients (insulin‐naïve, 13.0% ± 8.4%; insulin‐treated, 10.2% ± 7.8%) than in T1D patients (3.2% ± 3.2%). In T2D , NAFLD was associated with several markers of insulin resistance. In all three populations, there was an absence of association of HbA1c with LFC , but insulin doses were higher in patients with NAFLD .