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Evaluation of subcutaneous glucose monitoring systems under routine environmental conditions in patients with type 1 diabetes
Author(s) -
Aberer Felix,
Hajnsek Martin,
Rumpler Markus,
Zenz Sabine,
Baumann Petra M.,
Elsayed Hesham,
Puffing Adelheid,
Treiber Gerlies,
Pieber Thomas R.,
Sourij Harald,
Mader Julia K.
Publication year - 2017
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12907
Subject(s) - continuous glucose monitoring , medicine , type 2 diabetes , diabetes mellitus , type 1 diabetes , endocrinology
Continuous and flash glucose monitoring ( GM ) systems have been established in diabetes care. We compared the sensor performance of 3 commercially available GM systems. A total of 12 patients with type 1 diabetes were included in a single‐centre, open‐label study in which the sensor performance of the A bbott FreeStyle libre ( A bbott), D excom G4 P latinum ( D excom) and M edtronic MiniMed 640G ( M edtronic) systems over 12 hours was compared during mimicked real‐life conditions (meals, exercise, hypo‐ and hyperglycaemia). Sensor performance was determined by fulfilment of ISO 15197:2013 criteria, calculating mean absolute relative difference ( MARD ), and was also illustrated using P arkes error grid and B land– A ltman plots. Sensor performance during changes in metabolic variables (lactate, betahydroxybutyrate, glucagon, non‐esterified‐fatty‐acids) was determined by S pearman's rank correlation coefficient testing. The systems fulfilled ISO 15197:2013 criteria by 73.2% ( A bbott), 56.1% ( D excom) and 52.0% ( M edtronic). The MARDs ± standard deviation in the entire glycaemic range were 13.2% ± 10.9% ( A bbott), 16.8% ± 12.3% ( D excom) and 21.4% ± 17.6% ( M edtronic), respectively. All sensors performed less accurately during hypoglycaemia and best during hyperglycaemia. We did not observe an influence of metabolic variables on sensor performance.