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Effects of renal impairment on the pharmacokinetics and pharmacodynamics of a novel dipeptidyl peptidase‐4 inhibitor, evogliptin ( DA ‐1229)
Author(s) -
Oh Jaeseong,
Kim Andrew HyoungJin,
Lee SeungHwan,
Cho Hyunjeong,
Kim Yon Su,
Bahng Mi Young,
Yoon Seo Hyun,
Cho JooYoun,
Jang InJin,
Yu KyungSang
Publication year - 2017
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12813
Subject(s) - pharmacodynamics , pharmacokinetics , dipeptidyl peptidase 4 , renal function , urine , dipeptidyl peptidase , pharmacology , medicine , chemistry , endocrinology , enzyme , diabetes mellitus , biochemistry , type 2 diabetes
Evogliptin is a novel potent and selective dipeptidyl peptidase‐4 ( DPP ‐4) inhibitor. The aim of the present study was to evaluate the pharmacokinetic ( PK ) and pharmacodynamic ( PD ) characteristics of evogliptin in participants with renal impairment ( RI ). An open‐label, parallel‐group clinical study was conducted in participants with mild, moderate and severe RI and in matched participants with normal renal function ( NRF ). A single oral 5‐mg dose of evogliptin was administered and serial blood and urine samples were obtained to assess the PK and PD characteristics of evogliptin. Baseline urine samples were collected to evaluate endogenous CYP3A metabolic markers. The plasma exposure to evogliptin and degree of DPP ‐4 activity inhibition increased with decreasing renal function. The mean areas under the concentration–time curves from 0 to 120 hours were increased 1.2‐, 1.8‐ and 1.98‐fold in the mild, moderate and severe RI groups, respectively, compared with the NRF group. The levels of CYP3A metabolic markers were lower in the RI group than in the NRF group. The increase in the plasma concentration of evogliptin is unlikely to result in changes in its efficacy or safety, considering the results of previous clinical studies.