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Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial
Author(s) -
Grübler M. R.,
Gaksch M.,
Kienreich K.,
Verheyen N.,
Schmid J.,
ó Hartaigh B.,
Richtig G.,
Scharnagl H.,
Meinitzer A.,
FahrleitnerPammer A.,
März W.,
Tomaschitz A.,
Pilz S.
Publication year - 2016
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12709
Subject(s) - medicine , placebo , confidence interval , vitamin d and neurology , body mass index , post hoc analysis , randomized controlled trial , vitamin , endocrinology , glucose homeostasis , gastroenterology , lipid profile , glycated haemoglobin , diabetes mellitus , type 2 diabetes , obesity , insulin resistance , alternative medicine , pathology
Aim To investigate the efficacy of vitamin D supplementation on glycaemic control. Methods The Styrian Vitamin D Hypertension Trial was a single‐centre, double‐blind, placebo‐controlled study conducted between 2011 and 2014 at the Medical University of Graz, Austria. We enrolled 200 people with arterial hypertension and 25‐hydroxyvitamin D [25(OH)D] concentrations <30 ng/mL. Study participants were randomized to receive either 2800 IU of vitamin D or placebo per day for 8 weeks. The present study was a post hoc analysis that incorporated an analysis of covariance ( ancova ) approach, while adjusting for baseline differences. Results A total of 185 participants [mean ± standard deviation age, 60.1 ± 11.3 years; 47% women; mean 25(OH)D 21.2 ± 5.6 ng/mL, mean glycated haemoglobin (HbA1c) 44.8 ± 11.8 mmol/mol and mean body mass index 30.4 ± 5.4 kg/m 2 ] completed the trial. ancova showed a mean treatment effect [95% confidence interval (CI)] on HbA1c of −3.52 (−6.7 to −0.34) mmol/mol (p = .045). There was no difference in fasting glucose −4.7 mg/dL (95% CI −16.3 to 6.9; p = .426). Conclusions Vitamin D supplementation in obese hypertensive patients with low 25(OH)D reduces HbA1c levels. This finding warrants further investigation into potential vitamin D effects on glucose homeostasis.