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Randomized trial of a dual‐hormone artificial pancreas with dosing adjustment during exercise compared with no adjustment and sensor‐augmented pump therapy
Author(s) -
Jacobs P. G.,
El Youssef J.,
Reddy R.,
Resalat N.,
Branigan D.,
Condon J.,
Preiser N.,
Ramsey K.,
Jones M.,
Edwards C.,
Kuehl K.,
Leitschuh J.,
Rajhbeharrysingh U.,
Castle J.R.
Publication year - 2016
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12707
Subject(s) - medicine , dosing , glucagon , diabetes mellitus , type 1 diabetes , insulin , heart rate , endocrinology , blood pressure
Aims To test whether adjusting insulin and glucagon in response to exercise within a dual‐hormone artificial pancreas ( AP ) reduces exercise‐related hypoglycaemia. Materials and methods In random order, 21 adults with type 1 diabetes ( T1D ) underwent three 22‐hour experimental sessions: AP with exercise dosing adjustment ( APX ); AP with no exercise dosing adjustment ( APN ); and sensor‐augmented pump ( SAP ) therapy. After an overnight stay and 2 hours after breakfast, participants exercised for 45 minutes at 60% of their maximum heart rate, with no snack given before exercise. During APX , insulin was decreased and glucagon was increased at exercise onset, while during SAP therapy, subjects could adjust dosing before exercise. The two primary outcomes were percentage of time spent in hypoglycaemia (<3.9 mmol/ L ) and percentage of time spent in euglycaemia (3.9‐10 mmol/ L ) from the start of exercise to the end of the study. Results The mean (95% confidence interval) times spent in hypoglycaemia (<3.9 mmol/ L ) after the start of exercise were 0.3% (−0.1, 0.7) for APX , 3.1% (0.8, 5.3) for APN , and 0.8% (0.1, 1.4) for SAP therapy. There was an absolute difference of 2.8% less time spent in hypoglycaemia for APX versus APN (p = .001) and 0.5% less time spent in hypoglycaemia for APX versus SAP therapy (p = .16). Mean time spent in euglycaemia was similar across the different sessions. Conclusions Adjusting insulin and glucagon delivery at exercise onset within a dual‐hormone AP significantly reduces hypoglycaemia compared with no adjustment and performs similarly to SAP therapy when insulin is adjusted before exercise.

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