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Effect of antibiotics on gut microbiota, glucose metabolism and body weight regulation: a review of the literature
Author(s) -
Mikkelsen K. H.,
Allin K. H.,
Knop F. K.
Publication year - 2016
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12637
Subject(s) - gut flora , antibiotics , biology , obesity , type 2 diabetes , diabetes mellitus , metabolism , physiology , microbiology and biotechnology , endocrinology , immunology
Gut bacteria are involved in a number of host metabolic processes and have been implicated in the development of obesity and type 2 diabetes in humans. The use of antibiotics changes the composition of the gut microbiota and there is accumulating evidence from observational studies for an association between exposure to antibiotics and development of obesity and type 2 diabetes. In the present paper, we review human studies examining the effects of antibiotics on body weight regulation and glucose metabolism and discuss whether the observed findings may relate to alterations in the composition and function of the gut microbiota.