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Circadian clocks, obesity and cardiometabolic function
Author(s) -
Scott E. M.
Publication year - 2015
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12518
Subject(s) - zeitgeber , circadian rhythm , circadian clock , biology , chronobiology , clock , bacterial circadian rhythms , function (biology) , neuroscience , molecular clock , biological clock , microbiology and biotechnology , genetics , gene , phylogenetics
Life on earth is governed by the continuous 24‐h cycle of light and dark. Organisms have adapted to this environment with clear diurnal rhythms in their physiology and metabolism, enabling them to anticipate predictable environmental fluctuations over the day and to optimize the timing of relevant biological processes to this cycle. These rhythms are regulated by molecular circadian clocks, and current evidence suggests that interactions between the central and peripheral molecular clocks are important in metabolic and vascular functions. Disrupting this process through mutations in the core clock genes or by interfering with the environmental zeitgebers that entrain the clock appear to modulate the function of cells and tissues, leading to an increased risk for cardiometabolic disease.