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Brown adipose tissue triglyceride content is associated with decreased insulin sensitivity, independently of age and obesity
Author(s) -
Raiko J.,
Holstila M.,
Virtanen K. A.,
Orava J.,
Saunavaara V.,
Niemi T.,
Laine J.,
Taittonen M.,
Borra R. J. H.,
Nuutila P.,
Parkkola R.
Publication year - 2015
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12433
Subject(s) - triglyceride , medicine , endocrinology , adipose tissue , waist , body mass index , obesity , insulin , diabetes mellitus , cholesterol
The aim of the present study was to determine whether single‐voxel proton magnetic resonance spectroscopy ( 1 H‐MRS ) can non‐invasively assess triglyceride content in both supraclavicular fat depots and subcutaneous white adipose tissue ( WAT ) to determine whether these measurements correlate to metabolic variables. A total of 25 healthy volunteers were studied using 18 F ‐fluorodeoxyglucose positron emission tomography ( PET ) and 15 O‐H 2 O PET perfusion during cold exposure, and 1 H‐MRS at ambient temperature. Image‐guided biopsies were collected from nine volunteers. The supraclavicular triglyceride content determined by 1 H‐MRS varied between 60 and 91% [mean ± standard deviation (s.d.) 77 ± 10%]. It correlated positively with body mass index, waist circumference, subcutaneous and visceral fat masses and 8‐year diabetes risk based on the F ramingham risk score and inversely with HDL cholesterol and insulin sensitivity ( M ‐value; euglycaemic‐hyperinsulinaemic clamp). Subcutaneous WAT had a significantly higher triglyceride content, 76–95% (mean ± s.d. 87 ± 5%; p = 0.0002). In conclusion, the triglyceride content in supraclavicular fat deposits measured by 1 H‐MRS may be an independent marker of whole‐body insulin sensitivity, independent of brown adipose tissue metabolic activation.