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Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes
Author(s) -
Knudsen S. H.,
Karstoft K.,
Winding K.,
Holst J. J.,
Pedersen B. K.,
Solomon T. P. J.
Publication year - 2015
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12413
Subject(s) - endocrine system , type 2 diabetes , medicine , endocrinology , pancreatic function , diabetes mellitus , pancreas , hormone
We determined the effects of exercise on pancreatic endocrine responses to metabolic stimuli in subjects with type 2 diabetes ( T2D ) and examined the influence of subjects' diabetic status. Fourteen subjects underwent a hyperglycaemic clamp with glucagon‐like peptide‐1 ( GLP ‐1) infusion and arginine injection, the morning after a 1‐h walk or no exercise. Subjects were stratified by high and low fasting plasma glucose ( FPG ) levels and by glycated haemoglobin ( HbA1c ) levels, as well as by current use/non‐use of antidiabetic medication. In the entire cohort, exercise did not alter insulin secretion, while glucagon levels were increased in all clamp phases (p < 0.05 to <0.01). In subjects with low FPG levels, exercise increased GLP ‐1‐stimulated insulin secretion (p < 0.05), with the same trend being observed for arginine (p = 0.08). The same trends were seen for subjects with low HbA1c levels. Furthermore, exercise increased GLP ‐1‐ and arginine‐stimulated insulin secretion (p < 0.05) in subjects who were antidiabetic drug‐naïve. Exercise‐induced increases in insulin secretion are blunted in subjects with T2D with high rates of hyperglycaemia and in those using antidiabetic drugs.