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Simple lifestyle recommendations and the outcomes of gestational diabetes. A 2×2 factorial randomized trial
Author(s) -
Bo S.,
Rosato R.,
Ciccone G.,
Canil S.,
Gambino R.,
Poala C. B.,
Leone F.,
Valla A.,
Grassi G.,
Ghigo E.,
Cassader M.,
Menato G.
Publication year - 2014
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12289
Subject(s) - postprandial , medicine , gestational diabetes , randomized controlled trial , fasting glucose , diabetes mellitus , gestational age , pregnancy , glycated hemoglobin , obstetrics , endocrinology , physical therapy , gestation , type 2 diabetes , insulin resistance , biology , genetics
The benefits of exercise and behavioural recommendations in gestational diabetes mellitus ( GDM ) are controversial. In a randomized trial with a 2×2 factorial design, we examined the effect of exercise and behavioural recommendations on metabolic variables, and maternal/neonatal outcomes in 200 GDM patients. All women were given the same diet: group D received dietary recommendations only; group E was advised to briskly walk 20‐min/day; group B received behavioural dietary recommendations; group BE was prescribed the same as B + E. Dietary habits improved in all groups. In a multivariable regression model, fasting glucose did not change. Exercise, but not behavioural recommendations, was associated with the reduction of postprandial glucose (p < 0001), glycated haemoglobin ( HbA1c ; p < 0.001), triglycerides (p = 0.02) and C‐reactive protein ( CRP ; p < 0.001) and reduced any maternal/neonatal complications ( OR = 0.50; 95% CI =0.28–0.89;p = 0.02). In GDM patients a simple exercise programme reduced maternal postprandial glucose, HbA1c , CRP , triglycerides and any maternal/neonatal complications, but not fasting glucose values.