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Improved real‐world glycaemic outcomes with liraglutide versus other incretin‐based therapies in type 2 diabetes
Author(s) -
Lee W. C.,
Dekoven M.,
Bouchard J.,
Massoudi M.,
Langer J.
Publication year - 2014
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12285
Subject(s) - medicine , liraglutide , lira , type 2 diabetes , sitagliptin , confidence interval , logistic regression , metformin , exenatide , diabetes mellitus , endocrinology , insulin , exchange rate , economics , macroeconomics
Aim Liraglutide ( LIRA ) once‐daily has provided greater A1C reductions than either exenatide ( EXEN ) twice‐daily or sitagliptin ( SITA ) once‐daily in head‐to‐head trials. The objective of this analysis is to compare the real‐world clinical effectiveness of these agents in the USA . Methods Using the IMS Health (Alexandria, VA , USA) integrated claims database, A1C outcomes in patients aged ≥18 years with type 2 diabetes ( T2D ) who initiated either LIRA , EXEN or SITA (including SITA /metformin) were retrospectively compared. Patients included in the analysis had ≥1 prescription for LIRA , EXEN or SITA between January and December 2010 (index period) and persisted with their index treatment regimens for 6 months post‐index. Outcomes included changes in A1C from baseline (45 days pre‐index through 7 days post‐index) to follow‐up [6 months post‐index (±45)] and the proportion of patients reaching A1C <7%. Multivariable regression models adjusted for confounding factors (e.g. age, comorbidities, baseline A1C and background antidiabetic therapy). Results The predicted change in A1C from baseline was greater for LIRA patients compared with both SITA (−1.08 vs. −0.68%; treatment difference 0.40%, p < 0.0001) and EXEN (−1.08 vs. −0.75%; treatment difference 0.32%, p < 0.001). Predicted A1C goal achievement, derived from the multivariate logistic regression model, was higher with LIRA compared with both SITA [64.4% (95% confidence interval, CI : 63.5–65.3) vs. 49.4% (95% CI : 48.5–50.4); p < 0.0001] and EXEN [64.4% (95% CI : 63.5–65.3) vs. 53.6% (95% CI : 52.6–54.6); p < 0.0001]. Conclusions In clinical practice, LIRA was associated with significantly greater reductions in A1C and improved glycaemic goal attainment compared with either EXEN or SITA among adult patients with T2D .