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Ghrelin suppression is associated with weight loss and insulin action following gastric bypass surgery at 12 months in obese adults with type 2 diabetes
Author(s) -
Samat A.,
Malin S. K.,
Huang H.,
Schauer P. R.,
Kirwan J. P.,
Kashyap S. R.
Publication year - 2013
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12118
Subject(s) - ghrelin , postprandial , medicine , weight loss , endocrinology , gastric bypass surgery , type 2 diabetes , glucose homeostasis , diabetes mellitus , type 2 diabetes mellitus , insulin , gastric bypass , homeostasis , obesity , insulin resistance , hormone
Roux‐en‐Y gastric bypass ( RYGB ) surgery reverses type 2 diabetes mellitus ( T2DM ) in approximately 80% of patients. Ghrelin regulates glucose homeostasis, but its role in T2DM remission after RYGB surgery is unclear. Nine obese T2DM subjects underwent a mixed meal tolerance test before and at 1 and 12 months after RYGB surgery. Changes in ghrelin, body weight, glucagon‐like polypeptide‐1 ( GLP ‐1, glucose tolerance and insulin sensitivity (IS) were measured. At 1 month, body weight, glycaemia and IS were improved, while ghrelin concentrations were reduced (p < 0.05). After 12 months, body weight and fasting glucose were reduced (30 and 16%, respectively; p < 0.05) and IS was enhanced (threefold; p < 0.05). Ghrelin suppression improved by 32% at 12 months (p < 0.05), and this was associated with weight loss (r = 0.72, p = 0.03), enhanced IS (r = −0.78, p = 0.01) and peak postprandial GLP ‐1 (r = −0.73, p = 0.03). These data suggest that postprandial ghrelin suppression may be part of the mechanism that contributes to diabetes remission after RYGB surgery.