Premium
XMetA , an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet‐induced obesity
Author(s) -
Bhaskar V.,
Lau A.,
Goldfine I. D.,
Narasimha A. J.,
Gross L. M.,
Wong S.,
Cheung B.,
White M. L.,
Corbin J. A.
Publication year - 2013
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/dom.12019
Subject(s) - insulin resistance , endocrinology , medicine , allosteric regulation , monoclonal antibody , insulin receptor , obesity , insulin , receptor , antibody , immunology
XMetA , a high‐affinity, fully human monoclonal antibody, allosterically binds to and activates the insulin receptor ( INSR ). Previously, we found that XMetA normalized fasting glucose and glucose tolerance in insulinopenic mice. To determine whether XMetA is also beneficial for reducing hyperglycaemia due to the insulin resistance of obesity, we have now evaluated XMetA in hyperinsulinemic mice with diet‐induced obesity. XMetA treatment of these mice normalized fasting glucose for 4 weeks without contributing to weight gain. XMetA also corrected glucose tolerance and improved non‐high density lipoprotein cholesterol. These studies indicate, therefore, that monoclonal antibodies that allosterically activate the INSR , such as XMetA , have the potential to be novel agents for the treatment of hyperglycaemia in conditions associated with the insulin resistance of obesity.