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D-pinitol (3-0-methyl chiroinositol), an active principle of the traditional antidiabetic plant Bougainvillea spectabilis. is claimed to exert insulin mimetic effects. This was investigated in severely hyperglycaemic (about 20mM) insulin requiring streptozotocin-diabetic mice. D-pinitol (5, 10 and IOOmg/kg, po) acutely (0-6h) decreased the hyperglycaemia in a dose-related manner (lOOmglkg Dpinitol decreased blood glucose by about 15% p<O.Ol versus vehicle-only control). The glucose lowering effect was greater when the D-pinitol was administered ip (IOOmglkg decreased plasma glucose about 20%, p<O.Ol). D-pinitol did not alter the rate of insulin induced (lU/Kg actrapid ip) glucose disappearance. In acute studies, glucose concentrations were not significantly affected by D-pinitol in normal non-diabetic and severely insulin resistant obese-diabetic ob/ob mice. In cultured rat L6 muscle cells, D-pinitol (I 0'3M) increased basal uptake of 2-deoxy-eHJ-glucose by 41% after 10 min (p<0.05) and 34% after 4 h (p<0.05). D-pinitol did not increase insulinstimulated glucose uptake. It has been suggested that Dpinitol may activate an intracellular signalling intermediate within a post-receptor pathway of insulin action affecting glucose uptake. Present data support the view that D-pinitol can exert an insulin-like effect to improve glycaemic control in insulinopenic diabetic mice.

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