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Association of glycaemic variables with trabecular bone score in post‐menopausal women with type 2 diabetes mellitus
Author(s) -
Depczynski B.,
Liew P. Y.,
White C.
Publication year - 2020
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.14303
Subject(s) - medicine , waist , diabetes mellitus , trabecular bone score , type 2 diabetes , type 2 diabetes mellitus , trabecular bone , endocrinology , advanced glycation end product , bone density , osteoporosis , glycation , quantitative computed tomography , body mass index
Aim To determine the relationship between bone microarchitecture, as measured by trabecular bone score, and advanced glycation end‐product accumulation, as assessed by skin autofluorescence. Methods This was a cross‐sectional study. Participants were 64 post‐menopausal women with type 2 diabetes and 175 post‐menopausal women without diabetes. Trabecular bone score and skin autofluorescence data were obtained at time of bone density measurement. Results Trabecular bone score and skin autofluorescence were inversely correlated in women with type 2 diabetes ( r = –0.34, P = 0.006); no correlation was seen in post‐menopausal women without diabetes ( r = –0.029, P = 0.707). After adjustment, neither skin autofluorescence nor a diagnosis of diabetes were associated with trabecular bone score, but HbA 1c and waist circumference were independently associated with trabecular bone score. Conclusion Skin autofluorescence did not predict trabecular bone score. In contrast, glycaemia, as reflected by HbA 1c , and visceral adiposity, as reflected by waist circumference, were independently associated with trabecular bone score.