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Use of sensor‐integrated pump therapy to reduce hypoglycaemia in people with Type 1 diabetes: a real‐world study in the UK
Author(s) -
Choudhary P.,
Portu S.,
Arrieta A.,
Castañeda J.,
Campbell F. M.
Publication year - 2019
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.14043
Subject(s) - medicine , insulin pump , percentile , type 1 diabetes , diabetes mellitus , type 2 diabetes , insulin delivery , insulin , biomedical engineering , endocrinology , statistics , mathematics
Aims To assess the efficacy of insulin pumps with automated insulin suspension systems in a real‐world setting. Methods We analysed anonymized data uploaded to CareLink ™ by people ( n =920) with Type 1 diabetes using the MiniMed Paradigm Veo system and the MiniMed 640G system (Medtronic International Trading Sàrl, Tolochanez, Switzerland) with SmartGuard technology, with or without automated insulin suspension enabled, between February 2016 and June 2018. Users with ≥15 days of sensor data and ≥70% sensor‐wear time were classified as sensor‐augmented pump alone, sensor‐integrated pump with low glucose suspend enabled or sensor‐integrated pump with predictive low glucose management enabled. Results The median (25 th –75 th percentile) system use was 161 (58–348) days. The median time spent with sensor glucose values ≤3 mmol/l was 0.8 (0.3–1.7)% in the sensor‐augmented pump group, 0.3 (0.1–0.7)% in the sensor‐integrated pump with low glucose suspend group, and 0.3 (0.1–0.5)% in the sensor‐integrated pump with predictive low glucose management group. In individuals switching from sensor‐augmented pump to sensor‐integrated pump with low glucose suspend ( n =31), there were significant reductions in the monthly rate of hypoglycaemic events <3 mmol/l (rate ratio 0.63, 95% CI 0.45–0.89; P =0.009) and in the percentage of time with glucose values ≤3 mmol/l [sensor‐augmented pump: 0.63% (95% CI 0.34–1.29), sensor‐integrated pump with low glucose suspend: 0.33% (95% CI 0.16–0.64); P =0.001]. The monthly rate of hypoglycaemic events decreased further in individuals ( n =139) switching from sensor‐integrated pump with low glucose suspend to sensor‐integrated pump with predictive low glucose management [rate ratio 0.82 (95% CI 0.69–0.98); P <0.0274]. Similar results were seen for events <3.9 mmol/l. There was no difference in median time spent in target glucose range. Conclusion Real‐world UK data show that increasing automation of insulin suspension reduces hypoglycaemia exposure in people with Type 1 diabetes.

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